Trichloroacetic acid
CAS Number: 76-03-9
Chemical Formula: C2HCl3O2
Synonyms:
TCA
Deblock trichloroacetic acid solution
Appearance: Colorless crystals
HS Code: 29154000
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
Trichloroacetic acid, commonly abbreviated as TCA, appears as colorless or white orthorhombic crystalline solid. It shows strong hygroscopicity and emits a mild special pungent odor. This compound is highly corrosive. It has a molecular weight of 163.40, a relative density of 1.6298 at 61°C, a melting point range of 57–58°C, and a boiling point of 197.5°C (141–142°C at 3.333×10³ Pa). Its combustion heat is 3.0 kJ, refractive index is 1.4603 at 61°C, and vapor pressure is 0.133×10³ Pa at 51°C. TCA dissolves readily in water, forming an acidic solution (pH 1.2 for 0.1 mol/L aqueous solution). It is also soluble in ethanol and diethyl ether. At 25°C, its solubility values are 1306 in water, 2143 in methanol, and 617 in diethyl ether. Aqueous solutions with concentration below 30% decompose slowly into chloroform, hydrogen chloride, carbon dioxide, and carbon monoxide. In dilute alkaline solutions, TCA hydrolyzes into chloroform and carbon dioxide; in concentrated alkaline solutions, it forms formic acid. Reaction with strong alkalis yields chloroform and carbonate.
Parameters
| Parameter | Value |
| Melting point | 54-58 °C (lit.) |
| Boiling point | 196 °C (lit.) |
| density | 1.62 g/mL at 25 °C (lit.) |
| bulk density | 900kg/m3 |
| vapor density | <1 (vs air) |
| vapor pressure | 1 mm Hg ( 51 °C) |
| refractive index | n20/D 1.62(lit.) |
| Fp | 196°C |
| storage temp. | Store at +15°C to +25°C. |
| solubility | H₂O: 0.5 M at 20 °C, clear, colorless |
| pka | 0.7(at 25℃) |
| form | Solid |
| color | White |
| Odor | sharp, pungent odor |
| PH | <1.0 (25℃, 0.5M in H2O) |
| Water Solubility | 120 g/100 mL (20 ºC) |
| Sensitive | Hygroscopic |
| λmax | 210nm(EtOH)(lit.) |
| Merck | 14,9627 |
| BRN | 970119 |
| Exposure limits | ACGIH: TWA 0.5 ppm; NIOSH: TWA 1 ppm(7 mg/m3) |
| Dielectric constant | 4.9（20℃） |
| Stability: | Stable, but moisture sensitive. Incompatible with water, strong bases. Note that the Merck Index states that this material is hydrolytically unstable in aqueous solution below 30% by weight. Decomposition products include carbon monoxide and carbon dioxide. The generation of these gases in a sealed container may lead to a pressure rise sufficient. |
| LogP | 1.330 |
| CAS DataBase Reference | 76-03-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetic acid, trichloro-(76-03-9) |
| IARC | 2B (Vol. 63, 84, 106) 2014 |
| EPA Substance Registry System | Trichloroacetic acid (76-03-9) |
Safety Information
| Item | Details |
| Hazard Codes | Xn,N,C,F,Xi |
| Risk Statements | 36/37/38-40-51/53-50/53-35-38-11-34-67-52/53 |
| Safety Statements | 26-36/37-61-60-45-36/37/39-24/25-16 |
| OEB | B |
| OEL | TWA: 1 ppm (7 mg/m3) |
| RIDADR | UN 1839 8/PG 2 |
| WGK Germany | 2 |
| RTECS | AJ7875000 |
| F | 10-21 |
| Autoignition Temperature | 711 °C |
| Hazard Note | Corrosive/Hygroscopic |
| TSCA | Yes |
| HazardClass | 8 |
| PackingGroup | II |
| HS Code | 29154000 |
| Hazardous Substances Data | 76-03-9(Hazardous Substances Data) |
| Toxicity | LD50 orally in rats: 5000 mg/kg (Bailey, White) |
Product Application of Trichloroacetic acid CAS# 76-03-9
It serves as an extraction agent for adenosine triphosphate, cytochrome c, and placental lipopolysaccharide, as well as a protein precipitant. It is also widely used as an agricultural herbicide and a key raw material in organic synthesis.
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