Epichlorohydrin (Copy)Acetaminophen
CAS Number: 103-90-2
Chemical Formula: C8H9NO2
Synonyms: PARACETAMOL USP23 BP98， PARACETAMOL BP98，PARACETAMOL BP2001
Appearance: White Powder
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
Acetaminophen is a widely used analgesic and antipyretic agent. Unlike most non‑steroidal anti‑inflammatory drugs that block both COX‑1 and COX‑2, earlier research found it has relatively weak inhibitory activity against both isoforms. However, ex vivo tests in human blood show it inhibits COX‑2 by 83% and COX‑1 by 56% at a 1000 mg dose, with IC50 values of 25.8 μM and 113.7 μM respectively. Acetaminophen is converted both enzymatically and non‑enzymatically into several reactive metabolites that may cause side effects, including liver damage.
Chemical Properties
| Item | Value |
| Melting point | 168-172 °C(lit.) |
| Boiling point | 273.17°C (rough estimate) |
| density | 1.293 g/cm3 |
| vapor pressure | 0.008Pa at 25℃ |
| refractive index | 1.5810 (rough estimate) |
| Fp | 11 °C |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | ethanol: soluble 0.5M, clear, colorless |
| form | Crystals or Crystalline Powder |
| pka | 9.86±0.13(Predicted) |
| color | White |
| Odor | odorless |
| PH | 5.5-6.5 (H2O, 20℃)(saturated solution) |
| PH Range | 5.5 – 6.5 (H2O, 20 °C) (saturated solution) |
| explosive limit | 15%(V) |
| Water Solubility | 14 g/L (20 ºC) |
| Merck | 14,47 |
| BRN | 2208089 |
| BCS Class | 3,4 |
| Cosmetics Ingredients Functions | SKIN CONDITIONING |
| InChIKey | RZVAJINKPMORJF-UHFFFAOYSA-N |
| LogP | 1.098 at 25℃ |
| CAS DataBase Reference | 103-90-2(CAS DataBase Reference) |
| IARC | 3 (Vol. 50, 73) 1999 |
| NIST Chemistry Reference | Acetaminophen(103-90-2) |
| EPA Substance Registry System | Acetaminophen (103-90-2) |
Safety Information
| Item | Value |
| Hazard Codes | Xn,T,F |
| Risk Statements | 22-36/37/38-52/53-36/38-40-39/23/24/25-23/24/25-11 |
| Safety Statements | 26-36-61-37/39-22-45-36/37-16-7 |
| RIDADR | UN 3077 9/PG III |
| WGK Germany | 1 |
| RTECS | AE4200000 |
| Autoignition Temperature | 540 °C |
| TSCA | Yes |
| HazardClass | 9 |
| PackingGroup | III |
| HS Code | 29242930 |
| Hazardous Substances Data | 103-90-2(Hazardous Substances Data) |
| Toxicity | LD50 in mice (mg/kg): 338 orally (Starmer), 500 i.p. (Dahlin, Nelson) |
Product Application
Acetaminophen, internationally known as Paracetamol, is a common analgesic and antipyretic drug without anti‑inflammatory or anti‑rheumatic effects. Its fever‑reducing action is comparable to aspirin, while its analgesic effect is moderate. It is a leading aniline derivative and is especially suitable for people who cannot tolerate carboxylic acid drugs. It is used to relieve cold symptoms and toothache. It also serves as an intermediate in organic synthesis, a stabilizer for hydrogen peroxide, and a photographic chemical.
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