Sodium 4-aminosalicylate dihydrate
CAS Number: 6018-19-5
Chemical Formula: C7H10NNaO4
Synonyms: P-AMINOSALICYLIC ACID SODIUM SALT DIHYDRATE
PAS-NA 2H2O，SODIUM 4-AMINOSALICYLATE DIHYDRATE
Appearance: White crystal
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
Sodium 4-aminosalicylate dihydrate is a frequently used anti-tuberculosis pharmaceutical, also referred to as PAS-Na. It appears as a white or off-white crystalline powder, odorless with a sweet-salty taste. It dissolves readily in water, is slightly soluble in ethanol, poorly soluble in acetone, and nearly insoluble in diethyl ether, chloroform, and benzene. A 2% water solution shows a pH of 6.5–8. Aqueous solutions tend to degrade and form m-aminophenol, so fresh preparation is required before use.
Chemical Properties
| Parameter | Value |
| Melting point | 250 °C |
| RTECS | VO1700000 |
| storage temp. | 2-8°C |
| solubility | 956g/l |
| form | crystalline |
| color | white |
| PH | 6.5-8.5 (20g/l, H2O, 20℃) |
| Water Solubility | soluble |
| Sensitive | Air & Light Sensitive |
| CAS DataBase Reference | 6018-19-5(CAS DataBase Reference) |
Safety Information
| Item | Value |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29225090 |
Product Application
It is indicated for pulmonary and extrapulmonary tuberculosis caused by Mycobacterium tuberculosis. This agent is only active against mycobacteria and shows no effect on non-tuberculous mycobacteria. Resistance develops rapidly when used alone, so it must be combined with other anti-tuberculosis medications. Combined use with streptomycin and isoniazid can delay the emergence of drug resistance in Mycobacterium tuberculosis to these two drugs.
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