5-Bromo-2-chloropyrimidine
CAS Number: 32779-36-5
Chemical Formula: C4H2BrClN2
Synonyms: Macitentan Impurity 27,Macitentan Intermediate,5-BROMO-2-CHLOROPYRIMIDINE
Appearance: White Powder
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
5-Bromo-2-chloropyrimidine is a halogenated pyrimidine analog that carries chloro and bromo groups at the 2 and 5 positions of the pyrimidine ring system. This material acts as a vital pharmaceutical intermediate for producing macitentan, an endothelin receptor antagonist used in the management of pulmonary hypertension.
Chemical Properties
| Item | Value |
| Melting point | 73-79 °C (lit.) |
| Boiling point | 95°C 15mm |
| density | 1.859±0.06 g/cm3 (Predicted) |
| Fp | 95°C/15mm |
| storage temp. | Keep in dark place, Sealed in dry, Room Temperature |
| solubility | soluble in Methanol |
| pka | -2.84±0.22 (Predicted) |
| form | Crystalline Powder |
| color | Off-white to beige |
| Water Solubility | insoluble |
| BRN | 507955 |
| Stability | Hygroscopic |
| InChI | InChI=1S/C4H2BrClN2/c5-3-1-7-4(6)8-2-3/h1-2H |
| InChIKey | XPGIBDJXEVAVTO-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=C(Br)C=N1 |
| CAS DataBase Reference | 32779-36-5 (CAS DataBase Reference) |
Safety Information
| Item | Value |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/39-37/39-36 |
| RIDADR | UN 3335 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 29335990 |
Product Application
5-Bromo-2-chloropyrimidine is used as a pharmaceutical intermediate in the preparation of various pharmaceutical products including inhibitors. It is also applied in cross-coupling reactions between indium-based organometallic compounds and 2,5-dihalopyrimidines.
Supply & Delivery
Fast delivery time
Inventory 2-3 working days
New production 7-10 working days
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