Diethyl ethoxymethylenemalonate
CAS Number: 87-13-8
Chemical Formula: C10H16O5
Synonyms: 1,1-DICARBETHOXY-2-ETHOXYETHYLENE, 2,2-DICARBETHOXYVINYL ETHYL ETHER, AKOS BBS-00004230
Appearance: Colorless Liquid
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
Diethyl ethoxymethylenemalonate shows moderate toxicity if swallowed and can irritate the skin. It is a combustible liquid. When exposed to high temperatures for decomposition, it releases pungent and irritating fumes.
Chemical Properties
| Item | Value |
| Melting point | -33°C |
| Boiling point | 279-283 °C(lit.) |
| density | 1.080 g/mL at 20 °C(lit.) |
| vapor pressure | <0.1 hPa |
| refractive index | n20/D 1.463 |
| Fp | 311 °F |
| storage temp. | Store below +30°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Liquid |
| color | Clear colorless to light yellow |
| Water Solubility | insoluble |
| BRN | 880058 |
| InChI | 1S/C10H16O5/c1-4-13-7-8(9(11)14-5-2)10(12)15-6-3/h7H,4-6H2,1-3H3 |
| InChIKey | LTMHNWPUDSTBKD-UHFFFAOYSA-N |
| SMILES | CCO\C=C(\C(=O)OCC)C(=O)OCC |
| LogP | 1.5-2.1 at pH7 |
| CAS DataBase Reference | 87-13-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Propanedioic acid, (ethoxymethylene)-, diethyl ester(87-13-8) |
| EPA Substance Registry System | Propanedioic acid, (ethoxymethylene)-, diethyl ester (87-13-8) |
Safety Information
| Item | Value |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38-42/43 |
| Safety Statements | 26-36/37/39-27-24/25 |
| WGK Germany | 1 |
| RTECS | OO1100000 |
| Autoignition Temperature | 215 °C |
| TSCA | TSCA listed |
| HS Code | 29189090 |
| Storage Class | 10 – Combustible liquids |
| Hazard Classifications | Acute Tox. 4 Oral; Aquatic Acute 1; Aquatic Chronic 2; Eye Irrit. 2; Skin Irrit. 2; Skin Sens. 1A |
| Toxicity | LD50 orally in Rabbit: 925 mg/kg; LD50 dermal Rat > 2000 mg/kg |
Product Application
Diethyl ethoxymethylenemalonate is applied in the synthesis of pyrido[3,2-e]pyrimido[1,2-c]pyrimidines. It was first used to detect lysine decarboxylase activity. It supports amino acid analysis via precolumn derivatization in reversed‑phase HPLC. It is a key reagent in the Gould Jacobs reaction for quinoline synthesis, such as forming 4-hydroxyquinoline from aniline. It also serves as an intermediate for manufacturing flumequine, a fluoroquinolone antibiotic.
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Inventory: 2-3 working days
New production: 7-10 working days
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