Glycyrrhizic acid ammonium salt
CAS Number: 53956-04-0
Chemical Formula: C42H65NO16
Synonyms:
Glycyrrhizine ammonium salt
Monoammoniumglycyrrhetate
Monoammoniumglycyrrhizate
Appearance: Yellow Powder
HS Code: 29389090
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
Products Description of Glycyrrhizic acid ammonium saltCAS#53956-04-0
Ammonium Glycyrrhizinate features a strong sweet taste, roughly 200 times sweeter than sucrose. It is widely used as a sweetener in food additives, including canned meats, flavorings, candies, biscuits, preserved fruits, and drinks. Monoammonium glycyrrhizinate shows strong binding to hepatic sterol‑metabolizing enzymes, which helps prevent the breakdown of cortisol and aldosterone. When used, it provides noticeable glucocorticoid‑like benefits such as anti‑inflammatory and anti‑allergic effects and cell membrane protection, without the usual side effects of corticosteroid medicines.
Parameters
| Item | Value |
| Melting point | >200°C (dec.) |
| Boiling point | 768.56°C (rough estimate) |
| density | 1.1846 (rough estimate) |
| FEMA | 2528 | GLYCYRRHIZIN, AMMONIATED (GLYCYRRHIZA SPP.) |
| refractive index | 49 ° (C=1.5, EtOH) |
| storage temp. | 2-8°C |
| solubility | Slightly soluble in water, very slightly soluble in anhydrous ethanol, practically insoluble in acetone. It dissolves in dilute solutions of acids and of alkali hydroxides. |
| form | Powder or Crystals |
| color | Yellow to yellow-green |
| Odor | bland |
| optical activity | [α]20/D +48±4°, c = 1% in ethanol: water (1:1) |
| BRN | 3897076 |
| Stability | Hygroscopic |
| InChIKey | ILRKKHJEINIICQ-YDYGGSECSA-N |
| LogP | -0.9 |
| CAS DataBase Reference | 53956-04-0 |
| EPA Substance Registry System | .alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, monoammonium salt (53956-04-0) |
Safety Information
| Item | Value |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 2 |
| RTECS | LZ6500000 |
| F | 3-10 |
| HS Code | 29389090 |
Product Application of Glycyrrhizic acid ammonium salt CAS#53956-04-0
Ammonium Glycyrrhizinate is used in making polyion complex nanocarriers, which can serve as a blueprint for developing other water‑soluble drugs with negative charges. It works well with many anti‑inflammatory drugs. It is a flavor and sweet ingredient derived from licorice flavonoids, offering mild licorice taste and full‑bodied sweetness. It dissolves in water, glycerin, and propylene glycol, with good heat stability, though long heating may cause degradation. It stays stable at pH 3.5–9 but may precipitate below pH 3.5. Suitable uses include drinks, desserts, confectionery, soups, and sauces.
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