Dexamethasone
CAS Number: 50-02-2
Chemical Name: Dexamethasone
Molecular Formula: C₂₂H₂₉FO₅
Molecular Weight: 392.45
Synonyms: Dexamethasone Base, Dexamethasonum, Dexamethason; Dexamethasone Sodium Phosphate EP Impurity A
Appearance: Off-white crystalline powder
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
Dexamethasone is a synthetic glucocorticoid with high medicinal value. It delivers multiple potent pharmacological activities, including anti-inflammatory, anti-toxic and anti-allergic effects.
Mechanism of Action
It can regulate the survival, proliferation and differentiation of T cells, and block the induction of nitric oxide synthase in the body, so as to exert its therapeutic effects on inflammatory and allergic conditions.
Chemical Properties
| Parameter | Value |
| Melting point | 262-264 °C (lit.) |
| alpha | 75 º (c=1, dioxane) |
| Boiling point | 568.2±50.0 °C(Predicted) |
| density | 1.1283 (estimate) |
| refractive index | 76 ° (C=1, Dioxane) |
| Fp | 9℃ |
| storage temp. | 2-8°C |
| solubility | ethanol: 1 mg/mL |
| form | powder |
| pka | 12.13±0.70(Predicted) |
| color | off-white |
| biological source | synthetic (organic) |
| Water Solubility | 10 mg/100 mL (25 ºC) |
| Sensitive | Light Sensitive |
| Merck | 142943 |
| BRN | 2066651 |
| BCS Class | 1 (CLogP), 3 (LogP) |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, acid anhydrides, acid chlorides. May be light sensitive. |
| InChIKey | UREBDLICKHMUKA-CXSFZGCWSA-N |
| CAS DataBase Reference | 50-02-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Prednisolone, 9alpha-fluoro-16alpha-methyl-(50-02-2) |
| EPA Substance Registry System | Dexamethasone (50-02-2) |
Safety Information
| Item | Value |
| Hazard Codes | Xi,Xn,T,F |
| Risk Statements | 43-40-36/37/38-20/21/22-42/43-39/23/24/25-23/24/25-11 |
| Safety Statements | 36/37-45-36-26-22-16 |
| RIDADR | UN1230 – class 3 – PG 2 – Methanol, solution |
| WGK Germany | 2 |
| RTECS | TU3980000 |
| TSCA | Yes |
| HS Code | 29372210 |
| Hazardous Substances Data | 50-02-2(Hazardous Substances Data) |
| Toxicity | LD50 oral in rat: > 3gm/kg |
Product Application
Clinical Applications & Usage Guidelines
It is one of the most widely used pharmaceutical raw materials in clinical treatment. Its main clinical indications include rheumatoid arthritis and various collagen-related disorders.
Important Usage Note: This ingredient only relieves and suppresses inflammatory responses, and is unable to eradicate the underlying primary diseases. Therefore, it is generally not used alone in clinical practice. Combined administration with other pharmaceutical agents is recommended to obtain the best therapeutic outcome.
Industrial Applications
Apart from pharmaceutical usage, dexamethasone acts as an important intermediate for organic synthesis. It is widely adopted in the manufacturing processes of dyes, finished medicines, rubber additives, pesticides, pigments and other chemical products.
Supply & Delivery
Fast delivery time
Inventory: 2-3 working days
New production: 7-10 working days
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