β-Estradiol
CAS Number: 50-28-2
Chemical Formula: C18H24O2
Synonyms: BETA-ESTRADIOL-16,16,17-D3，17BETA-ESTRADIOL-16,16,17-D3，β-Estradiol, 99% (dry wt.), ca 3% water
Appearance: White solid
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
Estradiol is a steroid hormone secreted mainly by ovarian follicles, corpus luteum, and placenta during pregnancy. It is the most vital and biologically active form among all estrogens.
Chemical Properties
| Parameter | Value |
| Melting point | 178-179 °C(lit.) |
| alpha | D25 +76 to +83° (dioxane) |
| Boiling point | 355.44°C (rough estimate) |
| density | 1.0708 (rough estimate) |
| refractive index | 80.4 ° (C=1, Dioxane) |
| Fp | 2℃ |
| storage temp. | room temp |
| solubility | Practically insoluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent), slightly soluble in methylene chloride. |
| pka | pKa 10.71±0.02(H2O(0.1% p-dioxane) t=25±0.1 I=0.03(KCl))(Approximate) |
| form | powder |
| color | White to off-white |
| biological source | synthetic (organic) |
| Water Solubility | Soluble in dimethyl sulfoxide, ethanol, water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils. |
| Merck | 143703 |
| BRN | 1914275 |
| BCS Class | 1 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | VOXZDWNPVJITMN-ZBRFXRBCSA-N |
| CAS DataBase Reference | 50-28-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Estra-1,3,5(10)-triene-3,17beta-diol(50-28-2) |
| EPA Substance Registry System | Estradiol (50-28-2) |
Safety Information
| Item | Value |
| Hazard Codes | T,Xn,F |
| Risk Statements | 60-61-45-63-64-40-36-20/21/22-11-48 |
| Safety Statements | 53-22-36/37/39-45-36/37-26-16-36-20 |
| RIDADR | 2811 |
| WGK Germany | 3 |
| RTECS | KG2975000 |
| F | 45879 |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29372390 |
| Hazardous Substances Data | 50-28-2(Hazardous Substances Data) |
| Toxicity | LD50 subcutaneous in rat: > 300mg/kg |
Product Application
Estradiol serves as an estrogen pharmaceutical for functional uterine bleeding, primary amenorrhea, menopausal syndrome, and prostate cancer. It supports and regulates normal growth of female reproductive organs and secondary sexual traits. It encourages breast duct development and proliferation; at high doses, it suppresses prolactin release from the anterior pituitary gland and lowers milk production, and can be used to suppress lactation. Possible side effects include nausea, vomiting, and bleeding caused by excess endometrial hyperplasia. Caution is advised for individuals with impaired liver or kidney function. It is not intended for application on breast, vulva, or vaginal mucosa.
Supply & Delivery
Fast delivery time
Inventory: 2-3 working days
New production: 7-10 working days
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