Ketoconazole
CAS Number: 65277-42-1
Chemical Formula: C26H28Cl2N4O4
Synonyms: 4-(4-((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine
Appearance: White solid
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
Ketoconazole is a broad-spectrum imidazole antifungal agent. It acts with high selectivity by interfering with fungal cytochrome P-450 activity, thereby blocking the biosynthesis of ergosterol in fungal cell membranes. It works against both superficial and deep fungal infections. It not only restricts fungal growth but also prevents spores from turning into mycelium to stop further infection. It inhibits microbes at low concentrations and exerts fungicidal effects at high concentrations. It shows activity against Candida, Chromomyces, Coccidioides, Histoplasma, Sporothrix, and Trichophyton species. Clinically, it is used to treat tinea manuum, tinea pedis, tinea corporis, tinea cruris, thrush, tinea versicolor, and cutaneous candidiasis.
Chemical Properties
| Parameter | Value |
| Melting point | 148-152 °C |
| Boiling point | 753.4±60.0 °C(Predicted) |
| density | 1.4046 (rough estimate) |
| refractive index | -10.5 ° (C=0.4, CHCl3) |
| Fp | 9℃ |
| storage temp. | 2-8°C |
| solubility | methanol : soluble 50mg/mL |
| pka | pKa 3.25/6.22(H2O,t =25,I=0.025) (Uncertain) |
| form | Off-white solid |
| color | white to light yellow |
| optical activity | [α]20/D -1 to 1°, c = 4 in methanol |
| Water Solubility | Soluble in DMSO, ethanol, chloroform, water, and methanol. |
| Merck | 145302 |
| BCS Class | 2 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| InChIKey | XMAYWYJOQHXEEK-OZXSUGGESA-N |
| LogP | 4.35 |
| CAS DataBase Reference | 65277-42-1(CAS DataBase Reference) |
Safety Information
| Item | Value |
| Hazard Codes | T,N,F |
| Risk Statements | 25-36/37/38-23/24/25-50/53-48/22-60-39/23/24/25-11 |
| Safety Statements | 36-45-36/37/39-26-61-60-53-36/37-16-7 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | TK7912300 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29349990 |
| Hazardous Substances Data | 65277-42-1(Hazardous Substances Data) |
| Toxicity | LD 50 in mice, rats, guinea pigs, dogs (mg/kg): 44, 86, 28, 49 i.v.; 702, 227, 202, 780 orally (Heel) |
Product Application
Ketoconazole is an imidazole antifungal medicine. It is widely used to treat athlete’s foot and severe dandruff. As a broad-spectrum antifungal compound and a CYP3A4 inhibitor, it is prescribed for candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis. It is also used to assess P-glycoprotein/CYP3A-limited bioavailability in monkey models, study interleukin 1-mediated antitumor activity, and investigate in vivo drug–drug interactions.
Supply & Delivery
Fast delivery time
Inventory: 2-3 working days
New production: 7-10 working days
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