Progesterone
CAS Number: 57-83-0
Chemical Formula: C21H30O2
Synonyms: PROGESTERONE-WATER SOLUBLE，PROGESTERONE PRIMOLUT
Appearance: Yellow powder
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
Progesterone is an endogenous steroid and progestogen hormone, serving as the primary progestogen in the human body. It is a 21‑carbon steroid hormone secreted by ovarian luteal cells and acts as a key intermediate in the synthesis of all steroid hormones. It exists in two crystalline forms, α‑type and β‑type, both with identical physiological activity. The α‑form crystallizes as orthorhombic white prisms from dilute ethanol, while the β‑form appears as orthorhombic white needles. Both forms are nearly insoluble in water but dissolve well in ethanol, ether, chloroform, acetone, dioxane, and concentrated sulfuric acid.
Chemical Properties
| Parameter | Value |
| Melting point | 128-132 °C (lit.) |
| alpha | 186 º (c=1, ethanol) |
| Boiling point | 394.13°C (rough estimate) |
| density | d23 1.166; d20 1.171 |
| refractive index | 182 ° (C=2, Dioxane) |
| Fp | 2℃ |
| storage temp. | room temp |
| solubility | H2O: 25 mg/mL, may be clear to slightly hazy |
| form | powder |
| color | Yellow to yellow-brown |
| biological source | synthetic (organic) |
| Water Solubility | <0.1 g/100 mL at 19 ºC |
| Merck | 7773 |
| BRN | 1915950 |
| BCS Class | 4 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | RJKFOVLPORLFTN-LEKSSAKUSA-N |
| LogP | 3.87 |
| CAS DataBase Reference | 57-83-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Progesterone(57-83-0) |
| EPA Substance Registry System | Progesterone (57-83-0) |
Safety Information
| Item | Value |
| Hazard Codes | Xn,T,F |
| Risk Statements | 40-45-62-36-20/21/22-11 |
| Safety Statements | 36/37-45-53-16 |
| RIDADR | UN 1648 3 / PGII |
| WGK Germany | 3 |
| RTECS | TW0175000 |
| HS Code | 29372390 |
| Hazardous Substances Data | 57-83-0(Hazardous Substances Data) |
| Toxicity | LD50 intraperitoneal in rat: 327mg/kg |
Product Application
Progesterone produces critical morphological effects on the endometrium under estrogen stimulation and is essential for sustaining pregnancy. In the late menstrual phase, it works with estrogen to drive endometrial maturation and transition from the proliferative to the secretory phase, supporting embryo implantation and development. During menstruation, it promotes complete endometrial shedding.
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