Hydroxyapatit
CAS Number: 1306-06-5
Chemical Formula: Ca5HO13P3
Synonyms:
CALCIUM PHOSPHATE, HYDROXIDE PURIFIED
Hydroxyapatite: (Calcium hydroxyapatite)
apatite,hydroxy
Appearance: White Solid
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
Product Details
Calcium hydroxyapatite features a distinctive structure enabling conductivity along hydroxide channels. Hydroxide anions occupy positions at (1/4,1/4,1/4) and (3/4,3/4,3/4) along the c‑axis, while mobile protons carry charge and produce measurable conductivity in M₁₀(PO₄)₆(OH)₂ materials. Proton transfer between electronegative oxygen sites forms water molecules within channel structures, supporting charge transport and overall conductivity.
The unit cell comprises two triangular prismatic subunits that form a vertically sided rhombic prism. Two horizontal mirror planes intersect the c‑axis at hydroxide layers located 1/4 and 3/4 of the cell height. Each vertical face of every subcell is centered at an inversion point of symmetry.
Parameters
| Property | Value |
| Melting point | 1100 °C(lit.) |
| density | 3.076 g/cm³(Temp: 18 °C) |
| storage temp. | 2-8°C |
| solubility | H₂O: 0.3 mg/mL, clear, colorless |
| form | solid |
| color | White |
| Water Solubility | insoluble H₂O [MER06] |
| Merck | 13,3500 |
| Cosmetics Ingredients Functions | BULKING SKIN CONDITIONING ABRASIVE ORAL CARE |
| InChI | InChI=1S/2Ca.H3O4P.H2O/c;;1-5(2,3)4;/h;;(H3,1,2,3,4);1H2/q2*+2;;/p-4 |
| InChIKey | CGMRCMMOCQYHAD-UHFFFAOYSA-J |
| SMILES | [Ca+2].[Ca+2].P([O-])([O-])([O-])=O.[OH-] |
| CAS DataBase Reference | 1306-06-5(CAS DataBase Reference) |
| EPA Substance Registry System | Hydroxylapatite (Ca5(OH)(PO4)3) (1306-06-5) |
Safety Information
| Item | Details |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | MY8434000 |
| F | 3-10 |
| TSCA | TSCA listed |
| HS Code | 28352600 |
| Storage Class | 13 – Non Combustible Solids |
| Hazardous Substances Data | 1306-06-5(Hazardous Substances Data) |
Product Application
In the 1970s, researchers discovered that sintered calcium hydroxyapatite (Ca₁₀(PO₄)₆(OH)₂, often shortened to CaHap) exhibits outstanding biocompatibility and non‑toxicity in femoral and mandibular bone environments. Since that time, CaHap has been widely employed as a biomaterial for artificial bones and teeth, as well as a functional filler in cements and polymeric materials. At present, CaHap‑based bone void fillers are commonly used in medical and dental applications worldwide.
During the 1980s, studies revealed that sintered CaHap is well‑tolerated by skin and soft tissues. This finding led to the development of percutaneous devices incorporating CaHap, including systems for continuous ambulatory peritoneal dialysis, intravenous hyperalimentation, blood pressure monitoring, and vascular access for nutritional support.
In recent years, extensive investigations into apatite chemistry—especially calcium hydroxyapatite—have uncovered many new uses. These include bone and dental implants, ion exchange media, chromatographic adsorbents for separating proteins and enzymes, catalysts, ionic conductors, and temperature or gas sensors.
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