Dihydromyricetin
CAS Number 27200-12-0
Chemical Formula C18H32O7
Synonyms
3,3’,4’,5,5’,7-hexahydroxy-flavanon
3,3’,4’,5,5’,7-hexahydroxy-2,3-dihydroflavanonol
2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4h-1-benzopyran-4-on
Appearance White Powder
MOQ Minimum Order Quantity 1 FCL Full Container Load
Dihydromyricetin CAS#27200-12-0
(+)-dihydromyricetin is an optically active substance with (2R,3R)-configuration. It acts as a natural metabolite, effective antioxidant, and antineoplastic compound. It belongs to secondary alpha-hydroxy ketones and is the enantiomer of (-)-dihydromyricetin.
Dihydromyricetin (DHM), also called ampelopsin, is a natural flavonoid widely found in Asian plants. A well-known source is Hovenia dulcis, which has long been used in traditional medicine to relieve alcohol intoxication and hangovers. DHM is widely used as a dietary supplement for hangover relief, as it helps lower blood alcohol concentration and protect the liver.
Dihydromyricetin offers multiple health benefits, including antimicrobial, anti-inflammatory, antioxidant, and anticancer activities. It also helps regulate lipid and glucose metabolism and supports controlled cell death with minimal harm to normal cells. Most notably, it shows strong liver-protective effects and has been studied for improving alcohol-induced liver damage and acute liver failure.
Dihydromyricetin Chemical Properties
| Item | Value |
| storage temp. | -20°C |
| solubility | DMSO: ≥5mg/mL (warmed) |
| Melting point | 239-241 °C |
| pKa | 7.38±0.60(Predicted) |
| Boiling point | 780.7±60.0 °C(Predicted) |
| density | 1.808±0.06 g/cm3(Predicted) |
| form | powder |
| color | white to beige |
| Stability: | Hygroscopic |
| Cosmetics Ingredients Functions | SKIN CONDITIONING |
| InChI | InChI=1S/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H/t14-,15+/m0/s1 |
| InChIKey | KJXSIXMJHKAJOD-LSDHHAIUSA-N |
| SMILES | [C@H]1(C2=CC(O)=C(O)C(O)=C2)OC2=CC(O)=CC(O)=C2C(=O)[C@@H]1O |
| LogP | 1.230 (est) |
| CAS DataBase Reference | 27200-12-0 |
Safety Information
| Item | Value |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| HS Code | 29329990 |
| Storage Class | 11 – Combustible Solids |
Product Application of Dihydromyricetin CAS#27200-12-0
Dihydromyricetin is widely used in research on adipogenesis and glucose uptake in 3T3-L1 pre-adipocytes. It is also applied in studies of antitumor effects, especially against liver cancer cells.
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