8-Hydroxyquinoline
CAS Number: 148-24-3
Chemical Formula: C9H7NO
Synonyms:
8-hydroxy-quinolin
8-OQ
8-Oxyquinolin
Appearance: Transparent Liquid
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
8-Hydroxyquinoline CAS#148-24-3
8-Hydroxyquinoline appears as white to cream-colored crystals or crystalline powder. It is insoluble in water and ether, but freely dissolves in ethanol, acetone, chloroform, benzene, and aqueous mineral acids. It easily forms stable metal chelates that may be soluble or form precipitates in organic solvents based on solution pH (Hollingshead, 1954).
8-Hydroxyquinoline is a monohydroxyquinoline where a hydroxyl group is attached at the 8-position of quinoline. It features fungicidal activity used to manage gray mold in grapes and tomatoes. It functions as an antibacterial agent, iron chelator, antiseptic drug, and antifungal agrochemical. It is derived from the hydride of quinoline.
Parameters
| Melting point | 70-73 °C(lit.) |
| Boiling point | 267 °C752 mm Hg(lit.) |
| density | 1.0340 |
| vapor pressure | 0.221Pa at 25℃ |
| refractive index | 1.4500 (estimate) |
| Fp | 267°C |
| storage temp. | Store below +30°C. |
| solubility | 0.56g/l |
| form | Liquid |
| pka | 5.017(at 20℃) |
| color | White to pale yellow or light beige |
| Water Solubility | INSOLUBLE |
| Sensitive | Light Sensitive |
| Merck | 14,4843 |
| BRN | 114512 |
| Cosmetics Ingredients Functions | ANTIMICROBIAL CHELATING |
| InChIKey | MCJGNVYPOGVAJF-UHFFFAOYSA-N |
| LogP | 1.85 at 25℃ |
| CAS DataBase Reference | 148-24-3(CAS DataBase Reference) |
| IARC | 3 (Vol. 13, Sup 7) 1987 |
| NIST Chemistry Reference | 8-Quinolinol(148-24-3) |
| EPA Substance Registry System | 8-Quinolinol (148-24-3) |
Safety Information
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-68-36/37/38 |
| Safety Statements | 45-36/37/39-26-36 |
| RIDADR | 2811 |
| WGK Germany | 3 |
| RTECS | VC4200000 |
| Hazard Note | Harmful/Irritant |
| TSCA | TSCA listed |
| HazardClass | 9 |
| PackingGroup | III |
| HS Code | 29334990 |
| Hazardous Substances Data | 148-24-3(Hazardous Substances Data) |
| Toxicity | An LD50 value of 1,200mg/kg was reported for oral administration of 8-hydroxyquinoline to rats (strain/sex unspecified; AAPCO, 1966); a value of 48 mg/kg was reported for intraperitoneal administration to mice (strain/sex unspecified; Bernstein et al., 1963). |
Product Application of 8-Hydroxyquinoline CAS#148-24-3
8-Hydroxyquinoline (8HQ) serves as an intermediate for manufacturing halogenated quinoline anti-amebic medicines, including quiniodoform, clioquinoline, diiodoquinoline, and similar agents. These drugs achieve anti-amebic effects by suppressing intestinal commensal bacteria. They are effective against amoebic dysentery but inactive against extra-intestinal amoebic parasites.
8HQ is a small planar molecule with lipophilic characteristics and strong metal chelation capacity. Accordingly, 8HQ and its derivatives exhibit diverse pharmaceutical activities, including anti-neurodegenerative, anticancer, antioxidant, antimicrobial, anti-inflammatory, and antidiabetic effects.
Factory and Equipment Show
Fast delivery time
Inventory 2-3 working days New production 7-10 working days
Reviews
There are no reviews yet.